[2] Cerro Porteño 1-0 América de Cali [3] 2021-05-26 00:30
Stadium: General Pablo Rojas Round: 6
Referee: Nestor Fabian Pitana Home Manager: Francisco Arce Away Manager: Jersson Amur Gonzalez Diaz
Head to Head
| Copa Libertadores | 2021/04/22 02:00 | América de Cali v Cerro Porteño | W | 0-2 |
Home History
| Paraguay División Profesional | 2021/05/23 12:30 | Cerro Porteño v 12 de Octubre | L | 0-1 |
| Copa Libertadores | 2021/05/20 00:00 | Cerro Porteño v Atlético Mineiro | L | 0-1 |
| Paraguay División Profesional | 2021/05/16 21:45 | River Plate Asunción v Cerro Porteño | D | 1-1 |
| Copa Libertadores | 2021/05/13 00:00 | Deportivo La Guaira v Cerro Porteño | W | 0-1 |
| Paraguay División Profesional | 2021/05/09 00:00 | Cerro Porteño v Nacional Asunción | D | 2-2 |
| Copa Libertadores | 2021/05/04 22:15 | Atlético Mineiro v Cerro Porteño | L | 4-0 |
| Paraguay División Profesional | 2021/05/02 00:00 | Cerro Porteño v Olimpia Asunción | W | 2-0 |
| Copa Libertadores | 2021/04/28 22:00 | Cerro Porteño v Deportivo La Guaira | D | 0-0 |
Away History
| Copa Libertadores | 2021/05/20 02:00 | América de Cali v Deportivo La Guaira | W | 3-1 |
| Copa Libertadores | 2021/05/14 00:00 | América de Cali v Atlético Mineiro | L | 1-3 |
| Copa Libertadores | 2021/05/07 02:00 | Deportivo La Guaira v América de Cali | D | 0-0 |
| Colombia Primera A | 2021/05/01 23:00 | Millonarios v América de Cali | D | 0-0 |
| Copa Libertadores | 2021/04/27 22:15 | Atlético Mineiro v América de Cali | L | 2-1 |
| Colombia Primera A | 2021/04/24 20:30 | América de Cali v Millonarios | L | 1-2 |
| Copa Libertadores | 2021/04/22 02:00 | América de Cali v Cerro Porteño | L | 0-2 |
| Colombia Primera A | 2021/04/18 20:30 | América de Cali v Deportes Tolima | W | 2-0 |