Stadium: Sox Harrison Stadium Round: 1
| NCAAF | 2019/10/12 18:00 | Edinboro Fighting Scots v Mercyhurst Lakers | L | 23-44 |
| NCAAF | 2018/10/06 16:00 | Mercyhurst Lakers v Edinboro Fighting Scots | L | 24-6 |
| NCAAF | 2021/10/09 18:00 | Edinboro Fighting Scots v Slippery Rock | L | 13-49 |
| NCAAF | 2021/10/02 20:00 | Seton Hill Griffins v Edinboro Fighting Scots | W | 7-17 |
| NCAAF | 2021/09/25 16:00 | Edinboro Fighting Scots v California Vulcans | L | 12-20 |
| NCAAF | 2021/09/18 16:00 | West Chester Golden Rams v Edinboro Fighting Scots | L | 41-37 |
| NCAAF | 2021/09/11 16:00 | Edinboro Fighting Scots v Shippensburg Raiders | L | 9-30 |
| NCAAF | 2019/11/16 17:00 | Bloomsburg Huskies v Edinboro Fighting Scots | L | 20-17 |
| NCAAF | 2019/11/09 17:00 | Iup Crimson Hawks v Edinboro Fighting Scots | L | 35-6 |
| NCAAF | 2019/11/02 16:00 | Edinboro Fighting Scots v Clarion Golden Eagles | W | 27-20 |
| NCAAF | 2021/10/09 16:00 | Mercyhurst Lakers v Seton Hill Griffins | L | 17-19 |
| NCAAF | 2021/10/02 19:00 | California Vulcans v Mercyhurst Lakers | L | 37-0 |
| NCAAF | 2021/09/25 17:00 | Mercyhurst Lakers v Iup Crimson Hawks | L | 13-48 |
| NCAAF | 2021/09/18 17:05 | East Stroudsburg Warriors v Mercyhurst Lakers | L | 17-7 |
| NCAAF | 2021/09/11 16:00 | Mercyhurst Lakers v West Chester Golden Rams | L | 10-56 |
| NCAAF | 2021/09/04 22:00 | Mercyhurst Lakers v Alderson Broaddus Battlers | W | 18-3 |
| NCAAF | 2019/11/16 17:00 | Millersville University of Pennsylvania Marauders v Mercyhurst Lakers | W | 7-17 |
| NCAAF | 2019/11/09 17:00 | Clarion Golden Eagles v Mercyhurst Lakers | W | 10-57 |