Stadium: Stewart Stadium Round: 1
Home Manager: Jay Hill Away Manager: Ed McCaffrey
| NCAAF | 2021/11/06 18:00 | Montana v Northern Colorado | L | 35-0 |
| NCAAF | 2021/10/30 19:00 | CS Sacramento v Northern Colorado | L | 27-24 |
| NCAAF | 2021/10/24 00:00 | Northern Colorado v Southern Utah | W | 17-9 |
| NCAAF | 2021/10/17 00:00 | Northern Colorado v UC Davis | L | 3-32 |
| NCAAF | 2021/10/09 19:00 | East Washington v Northern Colorado | L | 63-17 |
| NCAAF | 2021/10/02 19:00 | Northern Colorado v Montana State | L | 7-40 |
| NCAAF | 2021/09/25 19:00 | Northern Arizona v Northern Colorado | W | 10-17 |
| NCAAF | 2021/09/18 20:00 | Lamar v Northern Colorado | L | 17-10 |
| NCAAF | 2021/11/13 21:00 | Weber State v Southern Utah | W | 62-0 |
| NCAAF | 2021/11/06 19:00 | Portland State v Weber State | L | 30-18 |
| NCAAF | 2021/10/30 19:00 | Weber State v Idaho State | W | 40-17 |
| NCAAF | 2021/10/23 20:00 | Weber State v East Washington | W | 35-34 |
| NCAAF | 2021/10/16 02:00 | Montana State v Weber State | L | 13-7 |
| NCAAF | 2021/10/03 00:35 | Weber State v Cal Poly | W | 38-7 |
| NCAAF | 2021/09/26 00:00 | UC Davis v Weber State | L | 17-14 |
| NCAAF | 2021/09/19 00:00 | James Madison v Weber State | L | 37-24 |