[4] Peñarol 1-0 Boston River [5] 2022-05-21 22:30
Stadium: Estadio Campeon del Siglo Round: 13
Referee: Gustavo Tejera Home Manager: Mauricio Larriera Away Manager: Ignacio Ithurralde
Head to Head
| Uruguay Clausura | 2021/09/26 18:30 | Boston River v Peñarol | W | 2-5 |
| Uruguay Apertura | 2021/05/30 21:00 | Peñarol v Boston River | W | 5-2 |
| Uruguay Clausura | 2021/02/07 00:45 | Boston River v Peñarol | W | 1-2 |
| Uruguay Torneo Intermedio | 2020/11/22 22:30 | Peñarol v Boston River | W | 2-0 |
| Uruguay Apertura | 2020/08/16 20:30 | Peñarol v Boston River | W | 2-0 |
| Uruguay Clausura | 2019/10/20 21:00 | Peñarol v Boston River | W | 1-0 |
| Uruguay Torneo Intermedio | 2019/07/14 21:00 | Peñarol v Boston River | W | 4-0 |
| Uruguay Apertura | 2019/03/30 22:00 | Boston River v Peñarol | W | 0-4 |
Home History
| Copa Libertadores | 2022/05/17 22:15 | Peñarol v Cerro Porteño | D | 0-0 |
| Uruguay Apertura | 2022/05/13 23:30 | Plaza Colonia v Peñarol | W | 0-1 |
| Uruguay Apertura | 2022/05/08 22:00 | Peñarol v Montevideo Wanderers | W | 1-0 |
| Copa Libertadores | 2022/05/05 00:00 | Olimpia Asunción v Peñarol | L | 1-0 |
| Copa Libertadores | 2022/04/28 00:00 | Cerro Porteño v Peñarol | L | 1-0 |
| Uruguay Apertura | 2022/04/23 22:00 | Torque v Peñarol | W | 0-1 |
| Uruguay Apertura | 2022/04/16 22:00 | Cerrito v Peñarol | D | 0-0 |
| Copa Libertadores | 2022/04/13 00:30 | Peñarol v Olimpia Asunción | W | 2-1 |
Away History
| Uruguay Apertura | 2022/05/16 21:00 | Boston River v Liverpool Montevideo | L | 2-3 |
| Uruguay Apertura | 2022/05/08 16:00 | Rentistas v Boston River | W | 0-1 |
| Uruguay Apertura | 2022/04/24 21:30 | Boston River v Deportivo Maldonado | W | 2-0 |
| Uruguay Apertura | 2022/04/15 19:00 | Danubio v Boston River | D | 0-0 |
| Uruguay Apertura | 2022/04/10 21:30 | Boston River v Nacional de Football | L | 0-6 |
| Uruguay Apertura | 2022/04/02 16:15 | Albion FC v Boston River | W | 1-2 |
| Uruguay Apertura | 2022/03/21 22:00 | Boston River v Defensor Sporting | D | 1-1 |
| Uruguay Apertura | 2022/03/12 19:30 | Atlético Fénix Montevideo v Boston River | W | 0-2 |