South Carolina 31-30 Clemson 2022-11-26 17:00
Stadium: Memorial Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Shane Beamer
Head to Head
| NCAAF | 2021/11/28 00:30 | Clemson v South Carolina | L | 30-0 |
| NCAAF | 2019/11/30 17:00 | Clemson v South Carolina | L | 38-3 |
| NCAAF | 2018/11/25 00:00 | South Carolina v Clemson | L | 35-56 |
| NCAAF | 2017/11/26 00:30 | Clemson v South Carolina | L | 34-10 |
| NCAAF | 2016/11/27 00:30 | South Carolina v Clemson | L | 7-56 |
| NCAAF | 2015/11/28 17:00 | South Carolina v Clemson | L | 32-37 |
| NCAAF | 2014/11/29 17:00 | Clemson v South Carolina | L | 35-17 |
| NCAAF | 2012/11/24 12:00 | Clemson v South Carolina | W | 17-27 |
Home History
| NCAAF | 2022/11/20 00:00 | Tennessee v South Carolina | W | 38-63 |
| NCAAF | 2022/11/12 21:00 | South Carolina v Florida | L | 6-38 |
| NCAAF | 2022/11/05 23:30 | South Carolina v Vanderbilt | W | 38-27 |
| NCAAF | 2022/10/29 20:00 | Missouri v South Carolina | L | 23-10 |
| NCAAF | 2022/10/22 23:30 | Texas A&M v South Carolina | W | 24-30 |
| NCAAF | 2022/10/08 23:30 | South Carolina v Kentucky | W | 24-14 |
| NCAAF | 2022/09/29 23:00 | South Carolina State v South Carolina | W | 10-50 |
| NCAAF | 2022/09/24 23:30 | Charlotte v South Carolina | W | 20-56 |
Away History
| NCAAF | 2022/11/19 20:30 | Miami Florida v Clemson | W | 10-40 |
| NCAAF | 2022/11/12 20:30 | Louisville v Clemson | W | 16-31 |
| NCAAF | 2022/11/05 23:30 | Clemson v Notre Dame | L | 14-35 |
| NCAAF | 2022/10/22 16:00 | Syracuse v Clemson | W | 21-27 |
| NCAAF | 2022/10/15 23:30 | Clemson v Florida State | W | 34-28 |
| NCAAF | 2022/10/08 23:30 | Clemson v Boston College | W | 31-3 |
| NCAAF | 2022/10/01 23:30 | NC State v Clemson | W | 20-30 |
| NCAAF | 2022/09/24 16:00 | Clemson v Wake Forest | W | 51-45 |