The UST Growling Tigers and Tigresses are the college athletic teams representing the University of Santo Tomas in the University Athletic Association of the Philippines. They hold the most UAAP Overall Championships with 45 Seniors' Overall Championships (out of 74 seasons) and 21 Juniors' Overall Championships (out of 26 seasons).
UST is one of four member universities that participate in all 15 sporting events of the league. They also take part in various sports leagues such as the Filoil Flying V Preseason Cup, the Premier Volleyball League and the UNIGAMES.