| WNCAAB | 11/22 23:00 | - | [135] USC Upstate - naised v Florida - naised [125] | L | 54-76 | |
| WNCAAB | 11/19 23:00 | - | USC Upstate - naised v Columbia International Women | W | 81-40 | |
| WNCAAB | 11/17 00:00 | - | South Carolina State - naised v USC Upstate - naised | W | 51-70 | |
| WNCAAB | 11/11 00:00 | - | [148] USC Upstate - naised v Clemson - naised [148] | L | 47-64 | |
| WNCAAB | 03/08 23:00 | 3 | [991] USC Upstate - naised v High Point - naised [21] | L | 63-85 | |
| WNCAAB | 03/06 19:00 | 122 | USC Upstate - naised v Charleston Southern - naised | W | 72-64 | |
| WNCAAB | 02/06 19:00 | - | UNC Asheville - naised v USC Upstate - naised | W | 58-61 | |
| WNCAAB | 02/05 19:00 | - | USC Upstate - naised v UNC Asheville - naised | W | 62-49 | |
| WNCAAB | 01/30 21:00 | - | USC Upstate - naised v Radford - naised | L | 45-54 | |
| WNCAAB | 01/29 23:00 | - | USC Upstate - naised v Radford - naised | L | 41-44 | |
| WNCAAB | 01/23 21:00 | - | USC Upstate - naised v Gardner Webb - naised | W | 70-68 | |
| WNCAAB | 01/22 23:00 | - | USC Upstate - naised v Gardner Webb - naised | L | 52-62 | |
| WNCAAB | 01/16 20:00 | - | Hampton - naised v USC Upstate - naised | W | 59-64 | |
| WNCAAB | 01/15 22:00 | - | Hampton - naised v USC Upstate - naised | L | 86-77 | |
| WNCAAB | 01/10 19:00 | - | USC Upstate - naised v Presbyterian - naised | L | 53-66 | |
| WNCAAB | 01/09 21:00 | - | USC Upstate - naised v Presbyterian - naised | L | 50-60 | |
| WNCAAB | 01/05 23:00 | - | Longwood - naised v USC Upstate - naised | L | 54-52 | |
| WNCAAB | 01/04 23:00 | - | Longwood - naised v USC Upstate - naised | L | 79-70 | |
| WNCAAB | 12/31 19:00 | - | USC Upstate - naised v High Point - naised | L | 48-70 | |
| WNCAAB | 12/30 19:00 | - | High Point - naised v USC Upstate - naised | L | 60-52 | |
| WNCAAB | 12/18 23:00 | - | Winthrop - naised v USC Upstate - naised | W | 49-56 | |
| WNCAAB | 12/17 23:00 | - | USC Upstate - naised v Winthrop - naised | L | 54-59 | |
| WNCAAB | 12/13 19:00 | - | Old Dominion - naised v USC Upstate - naised | L | 73-39 | |
| WNCAAB | 12/06 19:00 | - | USC Upstate - naised v Flagler Saints Women | W | 52-42 | |
| WNCAAB | 12/05 19:00 | - | USC Upstate - naised v St. Andrews Women | W | 84-40 | |
| WNCAAB | 12/03 00:00 | - | Alabama - naised v USC Upstate - naised | L | 98-59 | |
| WNCAAB | 11/26 00:00 | - | Auburn - naised v USC Upstate - naised | L | 82-41 | |
| WNCAAB | 03/10 23:00 | 1 | Winthrop - naised v USC Upstate - naised | W | 57-60 | |
| WNCAAB | 03/07 19:00 | - | USC Upstate - naised v Winthrop - naised | W | 66-59 | |
| WNCAAB | 03/05 00:00 | - | Longwood - naised v USC Upstate - naised | L | 69-56 |